The manufacture of filtered cannabis cigarettes : uniform particle distribution and combustion properties for consistent cannabinoid delivery

Here we describe a manufacturing process for the production of commercial filtered Cranfords cannabis cigarettes (CN). Unlike production of filtered tobacco cigarettes, standardization in the manufacture of cannabinoid containing cigarettes is lacking. The numerous cannabis strains with variable cannabinoid content, differences in cultivation methods and variability in assembly associated with hand-rolled cannabis cigarettes makes consistent cannabinoid inhalation dosing challenging. To address the growing need for standardization in the manufacture of cannabis cigarettes we developed a process for the production of filtered CN using machine-rolled tobacco cigarette equipment. The processed CN packing density, particle size distribution and curing procedures were designed to produce filtered CN that were identical in appearance and qualitatively similar in combustion properties to market-leading filtered commercial tobacco cigarettes. Quality control procedures were implemented to assure consistency in the manufacturing process and minimize variability associated with cigarette production such as inconsistencies in packing density, particle size, and combustion rate of mainstream smoke. Passive inverted smoldering assessment indicated that CN cigarettes burned at a faster rate compared to commercial filtered tobacco cigarettes of similar density. Overall, it is expected that machine-rolled standardized cannabis cigarettes with control over filler particle sizes, packing density and smoldering rates will contribute to making inhalation dosing of cannabis cigarettes more effective for therapeutic use. 1